Thus, SEP-GluA1-expressing neurons were exposed to a peptide (“PTEN-PDZ”; 5 or 10 μM) that blocks the interaction of PTEN with PDZ proteins, thereby preventing AMPAR endocytosis and synaptic depression, rescuing cognitive impairment in Alzheimer’s model mice17,70. The gene discussed is GRIA1; the disease is Cognitive impairment.