A recent study showed that blocking glutamine metabolism induced a divergent metabolic program between effector T cells and cancer cells to overcome tumor immune evasion.50 Similarly, Wang et al.51 reported that the combination of cystine depletion by cyst(e)inase and PD-L1 blockade synergistically enhanced T-cell-mediated antitumor immunity in melanoma in vivo. This evidence concerns the gene CD274 and melanoma.