CD274 and neoplasm: Though PD-1 inhibitors showed an exciting predominance on treating NPC, there were some NPC patients being reported to negatively respond to anti-PD-1 treatment.31, 32, 33 Wang et al., emphasized the prognostic significance of PD-L1 and PD-1 expression in patients with NPC, the expression status immune checkpoints in NPC patients might add prognostic value to the tumor staging system.34