Though PD-1 inhibitors showed an exciting predominance on treating NPC, there were some NPC patients being reported to negatively respond to anti-PD-1 treatment.31, 32, 33 Wang et al., emphasized the prognostic significance of PD-L1 and PD-1 expression in patients with NPC, the expression status immune checkpoints in NPC patients might add prognostic value to the tumor staging system.34 This evidence concerns the gene CD274 and nasopharyngeal carcinoma.