CD274 and nasopharyngeal carcinoma: Further, the expression of PD-1 and PD-L1 in locoregionally advanced NPC tissue significantly correlated with disease outcome and the response to immunotherapy including efficacy and safety.32, 35, 36, 37, 38, 39 In addition to PD-1/PD-L1 targeted immunotherapy, other targets of NPC have been reported.40