EYA2 and cancer: We also investigated the methylation status of EYA2 in all the 13 cancer types available in the TCGA pan-cancer database, and we discovered that seven types of tumor (BRCA, COAD, HNSC, KIRC, KIRP, LUAD and PRAD) were characterized by the hypermethylation of EYA2, while others (BLCA and UCEC) were characterized by its hypomethylation (Additional file 3: Fig. S6B).