We sacrificed each cohort of induced mice at 7, 9, and 11 months, and liver tumors were found in 100% (3/3) of the Eya2−/− mice at 9 months after DEN treatment, whereas no obviously macroscopic tumor was found in the Eya2+/+ group (Fig. 6J, K). Here, EYA2 is linked to neoplasm.