In particular, the median serum HMGB1 was 2.96 (± 7.45) ng/mL in WICAS and 7.65 (± 13.32) ng/mL in ICAS (p  <  0.001) patients; the median serum osteoprotegerin was 3.23 (± 2.25) pmol/L in WICAS and 6.86 (± 6.55) pmol/L in ICAS (p  <  0.001) patients; the median serum Hs-CRP was 7.92 (± 3.32) mg/L in WICAS and 16.7 (± 13.2) mg/L in ICAS (p  <  0.001) patients; the median serum IL-6 was 34.3 (± 14.5) pg/mL in WICAS and 52.4 (± 16.3) pg/ mL in ICAS (p  <  0.001) patients (Table 2). This evidence concerns the gene IL6 and familial isolated congenital asplenia.