After adjustment for traditional cardiovascular risk factors and established inflammatory cytokines, a multivariable stepwise logistic regression analysis, in model 1, showed that sex, age, smoking, hypertension, hypercholesterolemia, triglycerides, LDL-C, Hs-CRP and IL-6 levels were independent determinants of unstable plaque in diabetic patients with ICAS. The gene discussed is CRP; the disease is familial hypercholesterolemia.