As AATK/miR-1250 was frequently methylated in NHL primary samples, the tumor suppressor function of miR-1250-5p was studied by overexpression of miR-1250-5p in completely methylated NHL cells, including B-cell lymphoma SU-DHL-6 cells and T-cell lymphoma SU-DHL-1 cells. This evidence concerns the gene AATK and B-cell non-Hodgkin lymphoma.