In lung cancer cells, the oncogenic function of WDR1 in the regulation of cellular proliferation was shown to be mediated by dephosphorylation and hence increased nuclear translocation of YAP protein, a downstream effector for Hippo signaling pathway, hence activation of the transcription of pro-proliferative genes, such as cyclin A2, cyclin B1, cyclin D1, cyclin E and Cdk1 [41]. This evidence concerns the gene CCNE1 and lung cancer.