MAP3K1 and cancer: Two novel targets including Mitogen-Activated Protein Kinase 1 (MAPK1, also known as ERK2), a downstream effector for MAPK/ERK signaling pathway [26], and WD Repeat Domain 1 (WDR1, also known as Aip1), implicated in cancer cell migration and progression [27], were identified as putative targets of miR-1250-5p for further study (Fig. 5a).