GSEA analysis of 189 oncogenic gene sets identified the signature characteristics of genes downregulated in HEK293 cells upon knockdown of ATM (NES = 1.67; FDR = 0.062), genes upregulated in MCF10A cells (breast cancer) upon knockdown of BRCA1 (NES = 1.66; FDR =0.062); and genes downregulated in epithelial cells expressing the mutated form of KRAS (NES = 1.64; FDR = 0.062) to be the top 3 significantly enriched in EJ28P cells. The gene discussed is BRCA1; the disease is breast cancer.