Besides influencing the production of the adaptive cytokines IFN-γ and IL-22 (Fig. 1B), the TT genotype also impaired the secretion of proinflammatory cytokines, but not IL-10, by macrophages after 24 h of infection (Fig. 4A), a finding illustrating likely distinct regulatory mechanisms mediated by rs646564 across cell types. This evidence concerns the gene IFNG and infection.