Specifically, the rs674430 SNP was associated with a genotype-dependent effect on the production of tumor necrosis factor (TNF) (overall P = 0.012) and interleukin 6 (IL-6) (overall P = 0.013) by PBMCs after 24 h of infection (Fig. 1A), whereas the rs646564 SNP influenced gamma interferon (IFN-γ) (overall P = 0.011) and IL-22 (overall P = 0.016) produced by cells stimulated for 7 days (Fig. 1B). Here, TNF is linked to infection.