In autism, cannabis and cannabinoids have also been used to treat symptomatic conditions.16,17 CBD, and some other compounds in the plant, interact with the endocannabinoid system and can modulate different aspects related to cognition, socioemotional responses, susceptibility to seizures, nociception and neuronal plasticity, which are often altered in autism.18-21 In mammals, the endocannabinoid system is mainly composed of two receptors, CB1 and CB2, endocannabinoids (endogenous substances that activate CB1 and CB2 receptors) and the enzymes responsible for their synthesis and metabolism.22 The gene discussed is CNR2; the disease is autism.