Even though SK1 deletion does not cause a significant change in the inflammatory response in terms of leucocytes number in the MMTV-PyMT model, this does not rule out the possible impact of SK1 deficiency on the levels of different cytokines (TNFα, TGFβ, IL6) that have been shown to participate in cancer metastasis [42, 43]. The gene discussed is TGFB1; the disease is cancer.