Evaluation of the STAT3 pathway in the MMTV-PyMT SK1-/- mice will be important, due that a positive feedback loop between SK/S1P/S1PR/STAT3 has previously been described in inflammation associated colon cancer [62–64] and a positive correlation between SK1 and STAT3 expression was stablished in ER-negative breast cancer [65]. The gene discussed is SPHK1; the disease is malignant colon neoplasm.