Previous reports have presented mean or median MMP-8 levels of 49–71 ng/mL and 93 ng/mL, TIMP-1 mean or median levels of 310–413 ng/mL and 226–1687 ng/mL and median MMP-8/TIMP-1 molar ratios of 0.12 in patients with sepsis or critical illness at hospital or ICU admission or at sepsis onset whereas in the present study the mean day 3, 5 and 28 MMP-8 levels were higher and TIMP-1 levels were lower than earlier reported in sepsis or critical illness 13–15,23,25,26,29]. This evidence concerns the gene MMP8 and Sepsis.