In addition, the study found that the genetic disruption of hepatocyte DPP4 resulted in abrogation of obesity-associated increase of plasma DPP4 activity, repression of liver cytokine expression, and partly amelioration of inflammation in adipose tissue, however the incretin levels and glucose homeostasis were not affected [15]. Here, DPP4 is linked to obesity due to melanocortin 4 receptor deficiency.