The top CFA15 variant, BICF2G630433130, is located approximately 8 kilobases (kb) downstream of a 6 kb copy number variant (CNV) near the KIT ligand gene (KITLG) that was previously associated with variation in coat pheomelanin intensity in Nova Scotia Duck Tolling Retrievers and Poodles (S3 Fig in S1 Appendix) [32], as well as squamous cell carcinoma of the digit in eumelanistic, but not recessive red, Standard Poodles [49]. Here, KITLG is linked to squamous cell carcinoma.