WDR45 and retinal degeneration: Ophthalmic examination in mice from the phenotyping cohort (F4 generation) at around 13 months of age showed severe retinal degeneration in 5/13 Wdr45−/− and 5/15 Wdr45 −/Y mice, with clear altered OCT signal depicted in the SD-OCT images as a darker dotted pattern (Fig. 5a).