Most frequently mutated genes in AML included DNMT3A (36/103 patients, 34.95%), NRAS and ASXL1 (25/103 patients, 24.27%), TP53 (24/103 patients, 23.30%), FLT3, TET2, and RUNX1 (20/103 patients, 19.42%), and NPM1 (15/103 patients, 14.56%). The gene discussed is TP53; the disease is acute myeloid leukemia.