Of note, in addition to ARID1A, in one patient we also found mutations in ARID2 and SMARCA4 genes, which also belong to the SWI/SNF chromatin remodeling complexes, suggesting that impairment of this pathway may be a general mechanism of transformation in ZBTB16‐RARA+ AML. Here, ZBTB16 is linked to acute myeloid leukemia.