The high prevalence of ARID1A mutations in ZBTB16‐RARA+AML may extend the applicability of APR‐246 treatment, which also targets TP53‐mutations, and has shown efficacy in TP53 mutated cancers,36, 37 including MDS and AML.38, 39. Here, ZBTB16 is linked to myelodysplastic syndrome.