Using targeted NGS and studying 24 myeloid‐specific genes (listed in Table S2), we found that five of seven ZBTB16‐RARA+AML were mutated in at least one gene (71.42%), and the total number of mutated genes was 12 (mean of 1.71 ± SD 1.70 mutations/patient, Figure 1). Here, ZBTB16 is linked to acute myeloid leukemia.