However, the concentration of Wnt5a is elevated in the plasma and epicardial adipose tissue of patients with coronary artery disease (CAD) and independently associated with the presence of CAD and progression of calcified coronary plaque,86 and adipose tissue–derived Wnt5a in obesity induces arterial oxidative stress and migration of vascular smooth muscle cells (VSMCs) via activating a new Wnt5a/USP17/RAC1/NADPH oxidases axis.87 This evidence concerns the gene RAC1 and coronary artery disorder.