At present, studies on Wnt3 are mainly focused on its role in malignancies rather than in diabetes; we have revealed the carcinogenic role of Wnt3 in the development of gastric and colorectal cancers,39, 40 and the current few studies on Wnt3 are mainly about its role in diabetic complication of central nervous system. The gene discussed is WNT3; the disease is colorectal cancer.