However, in diabetic mice, the levels of Wnt5a and its receptor Fzd5 are significantly decreased in islet stellate cells (ISCs), a type of stellate cell located in islet and activated in T2DM, and down‐regulation of Wnt5a expression in ISCs could decrease insulin secretion,83 demonstrating a protective role of Wnt5a in maintaining the insulin secretion homeostasis of β‐cells. The gene discussed is INS; the disease is type 2 diabetes mellitus.