Moreover, Wnt2b is up‐regulated in serum of patients with DN and mesangial cells cultured in high glucose environment, and high glucose treatment could enhance the inflammation and extracellular matrix via activating the Wnt2b/β‐catenin pathway induced by two different long non‐coding RNAs, providing new mechanisms for understanding the development of DN and promising target for its treatment.37, 38. The gene discussed is WNT2B; the disease is liver dysplastic nodule.