Among all Wnts, Wnt10b is important negative regulator of adipocyte differentiation via activating the canonical Wnt pathway; lower Wnt10b expression and down‐regulation of Wnt10b/β‐catenin pathway are detected in white adipose and skeletal muscle tissues from men with overweight and prediabetes,120 and inactivation of Wnt10b/β‐catenin pathway promotes the adipogenesis and diet‐induced obesity in mice.121. Here, WNT10B is linked to obesity due to melanocortin 4 receptor deficiency.