WNT6 and obesity due to melanocortin 4 receptor deficiency: The expression level of Wnt6 is decreased during adipogenesis and ectopic expression of Wnt6 suppresses the differentiation of 3T3‐L1 pre‐adipocytes through a β‐catenin‐dependent pathway,101 and activation of Hedgehog signalling has been shown to prevent HFD‐induced obesity in mice by inducing the canonical Wnt6 pathway in adipose tissues.102