WNT5A and type 2 diabetes mellitus: Wnt5a is another regulator with dual function regarding the effect on islet function, induction of Wnt5a expression blocks glucose‐induced β‐cell proliferation,81 and treating β‐cells with exendin‐4, a glucagon‐like peptide‐1 receptor agonist regarded as a therapeutic reagent for T2DM, was found to promote β‐cell proliferation via inhibiting the expression of Wnt5a and mediated canonical Wnt pathway.82