Moreover, Wnt6 is expressed in mesonephros of the developing mouse embryo, and loss of Wnt6 is obvious in tubulointerstitium of patients with DN and animal models with renal fibrosis; therefore, activating the canonical Wnt6 pathway suppresses renal fibrosis through inhibiting TGF‐β1‐induced activation of NF‐κB pathway.103. This evidence concerns the gene NFKB1 and renal fibrosis.