The activation of ATF3/NFAT axis causes podocyte injury during the development of DN, and ATF3 is increased in glomeruli from proteinuric patients with DP, and Wnt6 is up‐regulated in ATF3‐overexpressed podocytes and identified as a target of this axis, indicating Wnt6 may aggravate podocyte injury and loss.104. The gene discussed is ATF3; the disease is liver dysplastic nodule.