Ando et al also showed that Wnt5a induced renal AQP2 expression via the activation of the non‐canonical Wnt5a/Ca2+ pathway could increase the urine concentration of mice with heritable nephrogenic diabetes insipidus (NDI), a hereditary disease characterized by defective urine concentration ability in kidney.97 This evidence concerns the gene WNT5A and nephrogenic diabetes insipidus.