LRP6 is required for the normal expression of insulin receptor and the stability of IGF receptor in humans, and a rare missense mutation in Wnt coreceptor LRP6 (R611C) is the aetiology of the autosomal dominant early‐onset coronary artery disease, T2DM and metabolic syndrome through blocking the canonical Wnt signalling.145, 146, 147. This evidence concerns the gene LRP6 and metabolic syndrome.