The expression level of Wnt6 is decreased during adipogenesis and ectopic expression of Wnt6 suppresses the differentiation of 3T3‐L1 pre‐adipocytes through a β‐catenin‐dependent pathway,101 and activation of Hedgehog signalling has been shown to prevent HFD‐induced obesity in mice by inducing the canonical Wnt6 pathway in adipose tissues.102. Here, WNT6 is linked to Obesity.