It has been widely reported that many AMPs display lower activity in environments of high salt concentration, including clavanins, tachyplesin, histatins and defensins.63–66 This is of particular therapeutic relevance for cystic fibrosis (CF) patients, who are at risk from opportunistic pathogens like P. aeruginosa, and who often suffer from chronic infections in the pulmonary mucus, which typically has an elevated salt concentration. Here, ADSL is linked to cystic fibrosis.