Previous work has reported that the DDR system comprises different pathways, including mismatch repair (MMR), base excision repair (BER), check point factors (CPF), Fanconi anemia (FA), homologous recombination repair (HRR), nucleotide excision repair (NER), nonhomologous end‐joining (NHEJ), and DNA translesion synthesis (TLS).23, 24. The gene discussed is NR5A2; the disease is Friedreich ataxia.