When we first included BMI, then anxiety/depression, then smoking and finally CRP, the proportion explained by each mediator changed only slightly (Supplementary Tables S6 and S7 and Supplementary Figure S5, available as Supplementary data at IJE online) and the conclusions regarding the main mediators of the associations between childhood maltreatment and CVD did not change. The gene discussed is CRP; the disease is major depressive disorder.