When we compared mediators for participants with prevalent and incident CVD, we found that prevalent CVD cases at baseline had a higher mean BMI and CRP, and were less likely to currently smoke than incident CVD cases; the prevalence of depression was similar in women with CVD at baseline and in women who developed CVD during follow-up, and higher in men with prevalent CVD than in men with incident CVD (Supplementary Table S8, available as Supplementary data at IJE online). Here, CRP is linked to major depressive disorder.