When we compared mediators for participants with prevalent and incident CVD, we found that prevalent CVD cases at baseline had a higher mean BMI and CRP, and were less likely to currently smoke than incident CVD cases; the prevalence of depression was similar in women with CVD at baseline and in women who developed CVD during follow-up, and higher in men with prevalent CVD than in men with incident CVD (Supplementary Table S8, available as Supplementary data at IJE online). The gene discussed is CRP; the disease is depressive disorder.