SNAP25 and hepatocellular carcinoma: Importantly, unlike HCC/A, full-length BoNT/A(0) can deliver LC/A(0) to the presynaptic terminal (Vazquez-Cintron et al., 2014) where, despite being catalytically inactive, LC/A(0) binds to SNAP-25 (Pellett et al., 2011), possibly interfering with SNARE complex function.