It was found that 17-AAG was capable of inhibiting antiapoptotic p-ERK1/2 proteins to promote early apoptosis for effective 17-AAG-mediated MTT and downregulating the expression of p-Akt to attenuate thermoresistance of cancer cells for realizing promoted low-temperature PTT (Figure 3(d)). The gene discussed is AKT1; the disease is cancer.