Tyrosine phosphorylation by dibenzyl diisopropylphosphoramidite was used in the development of non-peptide Grb2-SH2 ligands.60 Growth factor receptor-bound protein 2 (Grb2) is an adaptor protein between cell membrane receptors and cytoplasmic kinases and has been associated with breast and bladder cancers. The gene discussed is GRB2; the disease is urinary bladder carcinoma.