Furthermore, a positive association was observed between circulating PCSK9 with incidence of high triglycerides (HR 1.31, 95% CI 1.13–1.72, p < 0.001), hypertension (HR 1.28, 95% CI 1.08–1.53, p = 0.011), type 2 diabetes (HR 1.34, 95% CI 1.09–1.76, p = 0.005), and metabolic syndrome (HR 1.30, 95% CI 1.11–1.65, p = 0.009) in women only (Figure 2). This evidence concerns the gene PCSK9 and metabolic syndrome.