Although the best-described impact of PCSK9 is on the levels of LDL-cholesterol, data from epidemiological studies have shown that PCSK9 is also associated with certain features of cardiometabolic profiles including high-density lipoprotein (HDL) cholesterol, triglycerides, blood pressure, and fasting glucose, as well as insulin resistance (11–13). Here, PCSK9 is linked to Insulin resistance.