HLTF and Schimke immuno-osseous dysplasia: Mutations in SMARCAL1 lead to Schimke immuno-osseous dysplasia (SIOD), while HLTF/ZRANB3-deficient cells are vulnerable to replication stress and contribute to tumorigenesis (Ciccia et al., 2009; Li et al., 2009; Weston et al., 2012; Helmer et al., 2019).