Finally, nine candidate genes related to methylation were obtained, BASP1, VEGFA, MUC4, HLA-DRB1, TJP2, BCR, ANGPTL4, PKD1, and HK2, which may be involved in the pathogenesis of CHD (Figure 6B) and these genes information was provided in Supplementary Table 3. The gene discussed is PKD1; the disease is coronary artery disorder.