For example, AT1R and B2R heteromerization was found to occur in human placental biopsies from pregnancies complicated by preeclampsia, and the aberrant heteromerization of AT1R-B2R was found to result in exaggerated calcium signaling and high vascular smooth muscle mechanosensitivity (Quitterer et al., 2019). Here, BDKRB2 is linked to preeclampsia.