CD206+ M2 TAMs promote cancer progression by STAT-3 activation, inducing and maintaining a pro-carcinogenic microenvironment secreting high levels of VEGF, TGF-β, EGF, uPA, and several matrix metalloproteases (MMPs) promoting tumor progression, immunosuppression, angiogenesis, migration, metastasis and chemoresistance (37, 38). The gene discussed is MRC1; the disease is cancer.