In that work, mannose-coated polymeric nanoparticles containing mRNAs encoding interferon regulatory factor 5 (IRF5) and its activating kinase IKKβ, administered systemically, reverted M2-like TAMs to M1-like TAMs and increased the survival of mice with ovarian cancer, experimental metastasis of melanoma, and glioma, without any observed systemic toxicity. The gene discussed is IRF5; the disease is melanoma.