MRC1 and neoplasm: The importance in malignancy of M2-like TAMs is a general feature in many solid tumors besides OSCC; several studies indicated that CD163+, CD204+, and CD206+ M2-like macrophages that infiltrate the tumor microenvironment are significantly associated with poor prognosis in patients with lung cancer (50, 51), hepatocellular carcinoma, breast cancer, cervical cancer, multiple myeloma, and B-cell lymphoma (52).