In that work, mannose-coated polymeric nanoparticles containing mRNAs encoding interferon regulatory factor 5 (IRF5) and its activating kinase IKKβ, administered systemically, reverted M2-like TAMs to M1-like TAMs and increased the survival of mice with ovarian cancer, experimental metastasis of melanoma, and glioma, without any observed systemic toxicity. This evidence concerns the gene IRF5 and ovarian cancer.