The relative levels of both perforin (Figure 4C, Prf1) and granzyme (Figure 4D, Gsmf) observed in the tumor stroma were highly upregulated in the Trpa1-/- group, supporting the fact that in this group the CD8+ T cytotoxic effector function was more prevalent that in the wild type group. The gene discussed is CD8A; the disease is neoplasm.