BRAF and Langerhans cell histiocytosis: Similarly, the use of v-Raf murine sarcoma viral oncogene homolog B (BRAF) inhibitors for tumors harboring BRAF V600E mutations, including pediatric low grade gliomas, gangliogliomas, pleiomorphic xanthoastrocytomas and Langerhans Cell Histiocytosis, has extended survival for many of these patients (78).