Similarly, the use of v-Raf murine sarcoma viral oncogene homolog B (BRAF) inhibitors for tumors harboring BRAF V600E mutations, including pediatric low grade gliomas, gangliogliomas, pleiomorphic xanthoastrocytomas and Langerhans Cell Histiocytosis, has extended survival for many of these patients (78). This evidence concerns the gene BRAF and glioma.