BRAF and neoplasm: The choice of second-line treatment is individually tailored depending the therapeutic scheme received in the first-line setting (29, 31, 35–38) and its outcome and how well it was tolerated, patient fitness and clinical characteristics plus their tumor biologic and molecular features, especially rat sarcoma viral oncogene homolog (RAS)/v-raf murine sarcoma viral oncogene homolog B1 (BRAF) mutation status (2, 29, 31, 39, 40).