AID is expressed physiologically in GC B cells (8) and accordingly in GC-derived human B-cell lymphomas, such as diffuse large B-cell lymphoma (DLBCL), follicular B-cell lymphoma (FL), and Burkitt lymphoma (BL), which express AID constitutively (116–119). The gene discussed is AICDA; the disease is B-cell non-Hodgkin lymphoma.