In Neuro2a cells (N2a, mouse neuroblastoma cells), sterol regulatory element binding proteins (SREBPs) promote cholesterol synthesis via regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), the rate limiting enzyme in cholesterol synthesis (10), on transcription level (11). This evidence concerns the gene HMGCR and neuroblastoma.