In our study, MYCN-non-amplified human neuroblastoma cells, SH-SY5Y, were quite sensitive to the HMGCR and CYP17A1 inhibitors in vitro and in vivo, whereas SK-N-BE (2), a MYCN-amplified human neuroblastoma cell line, were also suppressed by the two inhibitors in combination in vitro. This evidence concerns the gene MYCN and neuroblastoma.