Some previous studies revealed that PLOD1 promoted tumorigenesis and metastasis in osteosarcoma, bladder cancer and esophageal squamous cell carcinoma (Wu et al., 2020; Yamada et al., 2019; Li et al., 2017), while the expression and prognostic role of PLOD1 in glioma remain to be further illustrated. Here, PLOD1 is linked to central nervous system cancer.