The current data verified that (i) DZNep alleviated CCl4-induced liver fibrosis in rats and in TGF-β1-activated HSCs; (ii) DZNep downregulated the expression of miR-199a-5p, and miR-199a-5p inhibition repressed TGF-β1-induced fibrosis markers expression; (iii) SOCS7 was a direct target of miR-199a-5p; and (iv) DZNep repressed fibrosis markers expression by upregulating SOCS7. Here, TGFB1 is linked to Hepatic fibrosis.