Having this background in mind, the aim of our study was to investigate the possible association between rs2741335 and rs11780592 EPHX2 polymorphisms with oxidized LDL (ox-LDL), carotid atherosclerosis, mortality, and CV disease in a cohort of T2DM patients with various degrees of renal function. The gene discussed is EPHX2; the disease is type 2 diabetes mellitus.