MYC and angiosarcoma: For radiation-associated and lymphedema-associated angiosarcoma high-level amplification of the proto-oncogene MYC is regarded one of the most common genetic alterations (Guo et al., 2011; Mentzel et al., 2012; Shon et al., 2014; Harker et al., 2017; Requena et al., 2018).