Consistently, The results showed that the genes mainly enriched in low risk population were typically involved in T cell activation/infiltration process, including the antigen processing and presentation, chemokine signaling pathway, cytokine-cytokine receptor interaction, T cell receptor signaling pathway, etc. Taken together, the risk score was validated as a good indicator for immune activity especially CD8+ T cell infiltration in melanoma patients. This evidence concerns the gene CD8A and melanoma.