For instance, active secretion of CXCL10 and CCL5 from TME is found to be associated with high infiltration of cytotoxic CD8+ T cells in colon cancer, and chemotactic migration of CD8+ T cells towards esophageal squamous cell carcinoma is greatly hampered with the treatment of anti-CXCL10 or anti-CCL5 neutralizing antibodies (59, 60). This evidence concerns the gene CD8A and malignant colon neoplasm.