In addition, EBI3-deficient C57BL/6 mice injected with B16 melanoma cells exhibits a significantly increased tumor growth relative to wild-type control mice, and tumors from EBI3-/- mice contains significantly decreased proportions of CD8+ T cells, suggesting a positive role of EBI3 in the infiltration of these cytotoxic T cells (64). The gene discussed is EBI3; the disease is melanoma.