For example, a mouse model of MPS IIIB had increased brain transcript levels of the cytokine IFN-γ and its receptor (55), and another study demonstrated in this model upregulation of over 120 gene transcripts related to both innate and adaptive components of the immune system including microglia, macrophages, T cells, Toll-like receptors (TLR), and cytokines (56). The gene discussed is IFNG; the disease is mucopolysaccharidosis type 3B.