Furthermore, Y111 enhanced the cytotoxicity of Vγ2Vδ2 T cells against various NSCLC cell lines with the secretion of IFNγ, TNFa, and Granzyme B. Furthermore, the combination of Y111 and transfused Vγ2Vδ2 T cells displayed effective inhibitory effects on the growth of the established xenograft in immunodeficient NPG mice. The gene discussed is GZMB; the disease is non-small cell lung carcinoma.