APLs, including IgG and IgM of anti-b2-glycoprotein I antibodies (also known as anti-b2-GPI; anti-APOH) and/or cardiolipin (aCL), and /or lupus anticoagulant, which have a clear correlation with the clinical manifestations of APS, but the pathophysiology between them is not clear (1, 4). The gene discussed is APOH; the disease is autoimmune polyendocrinopathy.