PNPLA3 and metabolic dysfunction-associated steatohepatitis: A recent study demonstrated that hepatic TG content was associated with significant increase in the PNPLA3-I148M (130). A more recent study to evaluate mechanisms underlying PNPLA3-I148M induced acceleration of NASH in a murine model where mice received a Western diet with ad lib administration of sugar in drinking water has revealed that under this type of diet, PNPLA3-I148M overexpression promotes steatosis and NASH.