It has repeatedly been shown that acid-sensing homomeric ASIC channels (ASIC1a and ASIC3; Deval and Lingueglia, 2015; Gründer and Chen, 2010) and TRP channels (TRPA1 and TRPV1; Caterina et al., 1997; Dai, 2016) respond to local acidosis during inflammatory and cancer pain (Deval and Lingueglia, 2015; Dai, 2016). The gene discussed is ASIC3; the disease is cancer.