The IPA core analysis of the putative molecular targets of cathine (Supplementary Table S8) and cathinone (Supplementary Table S9) revealed that canonical pathways such as G-protein coupled receptor signaling, dopamine receptor signaling, serotonin receptor signaling, CREB-signaling in neurons, Wnt signaling, FGF signaling, IL-6 signaling, ERK/MAPK signaling, endometrial cancer signaling, and cell cycle were significantly affected (p < 0.05). The gene discussed is CREB1; the disease is endometrial cancer.