CCN2 and renal fibrosis: NEAT1 is upregulated in CCl4 caused liver fibrosis, and it accelerates liver fibrosis progression (Yu et al., 2017; Kong et al., 2019); NEAT1 knockdown in HK2 cells inhibited the renal fibrosis-related markers TGF-β1 and CTGF (Yang et al., 2020).