TNF and orchitis: The targets are arranged in descending order according to their degree, the top 20 can be divided into 3 category: 1) ZBDHD target: GAPDH (294 edges), INS (290 edges), AKT1 (253 edges), MAPK3 (199 edges), SRC (166 edges), EGF (157 edges), CASP3 (153 edges); 2) Orchitis related targets: ALB (276 edges), CXCL8 (188 edges), IL10 (180 edges), STAT3 (167 edges), CAT (160 edges), IL2 (158 edges), IL4 (151 edges), HSP90AA1 (147 edges); 3) ZBDHD-orchitis target: IL6 (249 edges), TNF (227 edges), VEGFA (192 edges), IL1B (173 edges), TLR4 (168 edges).