Pantoprazole may cause increased incidence of hypoglycemia when prescribed with sitagliptin, may due in part that decreased renal excretion of sitagliptin via transporter OAT3 when coadministered with OAT3 inhibitors such as pantoprazole (Chu et al., 2007; Wang et al., 2019). The gene discussed is SLC22A8; the disease is Hypoglycemia.