Moreover, an enhanced sEH expression (resulting in low levels of EETs) in murine kidneys under streptozotocin-induced diabetes (Chen et al., 2012[3]; Bettaieb et al., 2017[2]; Jiang et al., 2020[23]) and in cells exposed to hyperglycemia (Jiang et al., 2020[23]) has been repeatedly observed. Here, EPHX2 is linked to diabetes mellitus.