TNNI3 and myocardial infarction: We found that the protective effect of MARK4 deficiency on the preservation of cardiac function was already apparent at 24 hours post-MI (Extended Data Fig.1b; Fig.2a), despite similar extent of myocardial injury, shown by comparable serum cardiac troponin I (cTnI) level (Fig.2b), and comparable infarct size analyzed by triphenyltetrazolium chloride (TTC) staining (Fig.2c), in Mark4-/- and wild-type mice.