Similarly to findings observed in PWS patients, Igfbp7 plasma levels were higher in PWScrp−/m+ mice than in WT mice, with a 2.2-fold increase (19.3 ng/ml ± 8.5 vs. 8.81 ng/ml ± 4.2, P = 0.0003) (Fig. 4b). Here, IGFBP7 is linked to Prader-Willi syndrome.