IGFBP7 may block IGF1R activity by competing with IGF1.17 IGFBP7 is mainly regulated by its messenger RNA (mRNA) expression and by proteolysis involving an editing process, with intact and cleaved forms of IGFBP7 displaying different biological activities.18–21 In cancer, the level of expression of IGFBP7 is variable depending on the cell type. Here, IGFBP7 is linked to cancer.