High IGFBP7 levels may be involved in degenerative mechanisms25,26 and, indeed, PWS is now considered as a degenerative disease.10 A potential positive effect of IGFBP7 modulation in the progression of neurodegeneration has been suggested.25 Alternatively, IGFBP7 levels have been associated with a decrease in infant brain volume.37 Therefore, decreasing IGFBP7 levels under GHT may have positive effects on the cognition of PWS patients.38 This evidence concerns the gene IGFBP7 and neurodegenerative disease.