Some studies have investigated the underlying mechanisms by showing that the intra-abdominal fat could secrete a variety of adipocytokines and inflammatory factors, which may change energy storage, insulin sensitivity, low-grade inflammatory responses, and abnormal blood coagulation22,23, thereby leading to insulin resistance and metabolic syndrome, such as hypertension, diabetes, dyslipidemia and coronary heart disease. Here, INS is linked to Insulin resistance.