Some studies have investigated the underlying mechanisms by showing that the intra-abdominal fat could secrete a variety of adipocytokines and inflammatory factors, which may change energy storage, insulin sensitivity, low-grade inflammatory responses, and abnormal blood coagulation22,23, thereby leading to insulin resistance and metabolic syndrome, such as hypertension, diabetes, dyslipidemia and coronary heart disease. The gene discussed is INS; the disease is Hypertension.